Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Recently, we highlighted that the ganglioside GM1 promotes neuroblastoma cells differentiation by activating the TrkA receptor through the formation of a TrkA-GM1 oligosaccharide complex at the cell surface.
|
30776097 |
2019 |
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The predictive value of NTRK1-pY674/pY675 together with wild-type TP53 and low PTPN6 expression could contribute to neuroblastoma patient prognosis.
|
30594749 |
2019 |
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Entrectinib's activity against both ALK and TRK proteins suggests a possible role in NB treatment, and it is currently under investigation in both pediatric and adult oncology patients.
|
30425456 |
2018 |
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The over-expressions of brain-derived neurotrophic factor (BDNF) and its tyrosine kinase receptor TrkB have been reported to induce chemo-resistance in neuroblastoma (NB) cells.
|
29959561 |
2018 |
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The aim of the present study was to investigate the effect of As<sub>2</sub>O<sub>3</sub> on Trk expression in NB cell lines and its potential therapeutic efficacy.
|
29898774 |
2018 |
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Collectively, these results indicate that EZH2 plays important roles in preventing the differentiation of NB cells and also that EZH2-related NTRK1 transcriptional regulation may be the key pathway for NB cell differentiation.
|
29507419 |
2018 |
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Consistent with this result, ZAR1-depleted NB cells showed well-differentiated phenotypes with elongated neurites and upregulated expression of TRKA and RET, which are markers for differentiated NB.
|
28791558 |
2017 |
Neuroblastoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Moreover, pathogenic <i>KIF1B</i>β mutations identified in neuroblastoma impair TRKA transport.
|
28637693 |
2017 |
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Elevated TrkA receptor expression is associated with all-trans retinoic acid-induced neuroblastoma differentiation.
|
26535632 |
2015 |
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Downregulation of TrkA protein expression by miRNA‑92a promotes the proliferation and migration of human neuroblastoma cells.
|
24839961 |
2014 |
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The treatment of NB cells with metformin or MIBG resulted in an increased expression of genes encoding biomarkers for favorable outcome in NB [(ephrin (EFN)B2, EFNB3, EPH receptor B6 (EPHB6), neurotrophic tyrosine kinase, receptor, type 1 (NTRK1), CD44 and Myc-interacting zinc finger protein (MIZ-1)] and tumor suppressor genes [(early growth response 1 (EGR1), EPH receptor A2 (EPHA2), growth arrest and DNA-damage-inducible, beta (GADD45B), neuregulin 1 (NRG1), TP53 apoptosis effector (PERP) and sel-1 suppressor of lin-12-like (C. elegans) (SEL1L)].
|
24190252 |
2014 |
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Expression of NTRK1/TrkA affects immunogenicity of neuroblastoma cells.
|
23400852 |
2013 |
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Exon-level expression analyses identify MYCN and NTRK1 as major determinants of alternative exon usage and robustly predict primary neuroblastoma outcome.
|
23047593 |
2012 |
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In particular with the high-risk factors such as age of patient >1 year, MYCN amplification and low TRKA expression, the decreased expression of KLF4 was significantly associated with an unfavorable NB outcome.
|
23045286 |
2013 |
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We analyzed the expression of the following genes in 814 NBs using quantitative real-time reverse transcriptase polymerase chain reaction (RT-PCR): NTRK1, NTRK2, NTRK3, P75/NGFR, nerve growth factor (NGF), BDNF, IGFR1, and EGFR.
|
21990266 |
2012 |
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The anaplastic lymphoma kinase (ALK) is a tyrosine kinase receptor that is involved in the pathogenesis of different types of human cancers, including neuroblastoma (NB).
|
21829174 |
2011 |
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Gene expression of TRK neurotrophin receptors in advanced neuroblastomas in Singapore--a pilot study.
|
21728718 |
2011 |
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
By directly connecting MYCN to the repression of TRKA and p75NTR, our findings establish a key pathway of clinical pathogenicity and aggressiveness in neuroblastoma.
|
21123453 |
2011 |
Neuroblastoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
NTRK1 c.1810C>T polymorphism appears to be a new independent prognostic factor of poor outcome in neuroblastoma, especially in children under 18 months of age with no MYCN amplification.
|
20003389 |
2009 |
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Trk-A, p75NRT, and GRP78 overexpression are favorable prognostic factors in pediatric neuroblastoma, whereas Trk-B is associated with a poorer prognosis in these tumors.
|
19386345 |
2009 |
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Expression of Trk receptors is an important prognostic factor in neuroblastoma (NB) and other cancers.
|
19363525 |
2009 |
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Here, we used the SH-SY5Y human neuroblastoma cell line ectopically expressing either TrkA or TrkB as a model system to analyze the impact of Trk receptor expression on NHEJ-mediated DSB repair.
|
18678285 |
2008 |
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Expression of Trk receptors has been implicated in the pathogenesis and prognosis of embryonal tumors, including neuroblastoma, nephroblastoma, and medulloblastoma.
|
17973327 |
2008 |
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Furthermore, MIZ-1 expression was positively correlated with the expression of favorable neuroblastoma genes (EFNB2, EFNB3, EPHB6, and NTRK1) in the human neuroblastoma xenograft therapeutic models.
|
17947461 |
2007 |
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The expression of KIT, PDGFRbeta, and FLT3 mRNA was associated with NB in patients under 1 year (P < 0.02) and TRKA expression (P < 0.001).
|
17941064 |
2008 |